【摘要】 目的探讨脂联素（APN）与T2DM及其大血管并发症的相关性。方法测定正常人群（NC组）与单纯T2DM患者（T2DM组）及其大血管病变患者（T2DM+MA组）血清APN、胰岛素、血糖、血脂水平。结果 （1）血清APN水平T2DM组及T2DM+MA组较NC组降低,T2DM+MA组较T2DM组更低,差异有统计学意义;（2）APN水平与BMI、WHR、HOMA-IR、FIns、HbA₁c、TG负相关。结论 T2DM及其大血管病变患者血清APN水平的降低,可能与T2DM及其大血管并发症的发生发展密切相关。更多还原

【Abstract】 Objective To explore the correlation of adipnectin with T2DM and its macrovascular complications.Methods The levels of serum adiponectin,plasma glucose,serum lipids,and fasting insulin were measured in normal subjects,type 2 diabetic patients and type 2 diabetic patients with macrovascular complications.Results （1）The serum adiponectin level was significantly lower in type 2 diabetic patients than in normal subjects,and was the lowest in type 2 diabetic patients with macrovascular complications.（2）Serum adiponetin level was negatively correlated with BMI,HOMA-IR,HbA₁c,TG and fasting insulin level.Conclusions The results suggest that lower serum adiponectin level may be related to macrovascular complications in type 2 diabetic patients.更多还原