希罗达治疗肝癌后的肝癌超微结构的变化

【摘要】 目的:了解希罗达治疗后的肝癌超微结构的变化。方法:通过术前服用希罗达与未服用希罗达肝癌手术切除标本的对比,了解肝癌经希罗达治疗后超微结构的变化。结果:希罗达治疗肝癌后肝癌超微结构的变化表现为细胞接触松弛,胞质空虚,线粒体肿胀或空泡化;粗面型内质网减少;核浆比例减少,常染色质减少;异染色质增多,可见核浓缩、碎裂或溶解,核仁缩小或消失,并可见凋亡小体。结论:希罗达治疗后肝癌超微结构的变化说明希罗达能诱导肝癌细胞发生凋亡并抑制其生长。更多还原

【Abstract】 Objective:Learn the influence Xeloda treatment to liver ultrastructural changes of liver cancer.Methods:By giving or not giving capecitabine preoperatively to patients who were ill with liver cancer,ultrastructure variation of liver cancer cell that was induced by capecitabine could be learned from the difference.Results:ultrastructure variation of live cancer cell induced by capecitabine were such follows:cell-cell junctions were loose,the cytoplasm was hollow,the mitochondria vacuolalized or swelled,Rouf-surfaced endoplasmic reticulum and eu-chromatin reduced,the ratio between nucleus and cytoplasm reduced too;heterochromatin increased.The nucleus condensed、segregated and dissolved;the nucleolus reduced or disappeared,and the apoptotic bodies could be found.Conclusion:The ultrastructure change of liver cancer treated by capecitabine showed that capecitabine could induce apoptosis and inhibit growth of liver cancer cell.更多还原