【摘要】 目的探讨三七总皂甙注射液对脓毒症患者凝血功能的影响。方法将50例无凝血功能障碍的脓毒症患者随机分为两组,对照组25例给予常规综合治疗,观察组25例加用三七总皂甙注射液治疗。分别检测两组患者治疗前,以及治疗后第1、3和7d静脉血血小板计数(Plt)、血浆凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体(D-D)浓度。结果观察组与对照组患者治疗前Plt、PT、TT、APTT、FIB和D-D值比较无明显差异(P均>0.05)。治疗后第7d两组Plt和FIB有明显差异(P<0.01,P<0.05)。对照组患者的PT、TT和APTT呈延长趋势,观察组患者的PT、TT和APTT无明显延长或有所缩短。与对照组比较,观察组患者第7d的PT、TT和APTT明显缩短(P均<0.05)。对照组患者的D-D浓度呈略升高趋势,观察组患者的D-D浓度稍升高后即逐渐下降,至治疗后第7d,两组间D-D浓度有显著差异(P<0.01)。结论三七总皂甙注射液对脓毒症患者的凝血功能有调节作用。更多还原

【Abstract】 Objective To study the effects of total saponins of panax notoginseseng injection on the coagulation function in sepsis.Methods 50 sepsis patients with normal coagulation function were randomly divided into two groups.25 patients in the control group received the routine treatment and the other 25 patients in the treatment group received total saponins of panax notoginseseng injection additionally.The levels of Plt,PT,TT,APTT,FIB and D-D were measured before the therapy and on 1st,3rd and 7th day after the therapy.Results The levels of Plt,PT,TT,APTT,FIB and D-D before the therapy had no significant differences between the two groups (P>0.05).The levels of Plt and FIB had significant differences between the two groups on 7th day after therapy (P<0.01,P<0.05).PT,TT,and APTT were prolonged in the controlled group gradually,but were not prolonged or even shortened in the treatment group,which were significantly shorter in the treatment group on 7th day after therapy (P<0.05).D-D slightly elevated in the control group,but slightly elevated at first and dropped gradually in the treatment group,which was significantly lower in the treatment group on 7th day after therapy.Conclusion Total saponins of panax notoginseseng injection has a protective effect on coagulation function in sepsis.更多还原