【摘要】 目的分析非综合征性唇腭裂(nsCL/P)与孕早期环境暴露因素之间的关系。方法选择在贵阳医学院附属医院和广西百色市人民医院就诊的212例nsCL/P患者作为病例组,221例外伤病人和骨折病人作为对照组。采用自行设计的调查表,通过面对面询问433例研究对象的父母亲获取问卷资料,运用单因素及多因素非条件Logis-tic回归模型分析环境危险因素与非综合征性唇腭裂的关联性。结果病例组父亲和母亲具有高中及以上文化程度的比例(37.7%,27.4%)明显低于对照组(60.6%,57.0%);病例组父亲和母亲为农民的比例(77.4%,77.8%)明显高于对照组(52.5%,52.5%);在调整了父母的文化程度和职业分布影响后,多因素分析结果显示,母亲孕早期被动吸烟(OR=1.643)、母亲孕早期感染史(OR=2.741)、父亲知晓怀孕前饮酒(OR=1.793)明显增加nsCL/P的发病风险。结论怀孕夫妇在孕早期应避免烟酒等不良嗜好并注意防止感染的发生,以减少后代患唇腭裂的风险。更多还原

【Abstract】 Objective To analyze the effects of environmental factors in the first trimester of pregnancy on development of nonsyndromic cleft lip with or without cleft palate(nsCL/P).Methods Totally 212 patients of nsCL/P and 221 controls with trauma or bone fracture were selected from the Affiliated Hospital of Guiyang Medical College and Baise People’s Hospital.A face-to-face questionnaire interview to parents of the subjects was conducted.The environmental risk factors were analyzed with unconditional univariate and multivariate logistic regression models.Results The ratios of the cases’ fathers and mothers with middle school education(37.7% and 27.4%) were lower compared with that of the controls’(60.6% and 57.0%).The ratios of the cases’ fathers and mothers being peasants(77.4% and 77.8%) were higher than that of the control group(52.5% and 52.5%).After adjusting for education level and occupation of father and mother,the results of multivariate analysis showed that maternal passive smoking(OR=1.643),infection(OR=2.741) in the first trimester of pregnancy,paternal alcohol drinking(OR=1.793) before realizing pregnancy were significant risk factors of nsCL/P.Conclusion It is important for gestation couple to avoid smoking,alcohol drinking and infection to prevent nsCL/P.更多还原