【摘要】 目的探讨超声检测胎儿大脑中动脉血流峰值流速(MCA-PSV)对产前预测重型α-地中海贫血的价值。方法超声检测399例不同孕龄胎儿MCA-PSV,显著升高(高于同孕龄胎儿中位数的1.5倍)者行脐静脉穿刺及基因诊断。结果 16例胎儿MCA-PSV显著升高,其中重型α-地中海贫血胎儿12例,重型β-地中海贫血1例,胎儿多发畸形并梅毒感染1例,假阳性2例。重度贫血胎儿MCA-PSV较同孕龄正常对照组胎儿MCA-PSV明显增高,两组差异有统计学意义(P<0.001)。以MCA-PSV高于同孕龄胎儿中位数的1.5倍为标准,超声预测重度胎儿贫血的敏感性为100%,假阳性为12.5%。结论超声检测MCA-PSV是产前预测胎儿重型α-地中海贫血的有效方法。更多还原

【Abstract】 Objective To investigate the diagnostic value of middle cerebral artery peak velocity (MCA-PSV) in forecasting severe a-thalassemia in fetuses with ultrasound.Methods MCA-PSV in 399 fetuses was gained.Umbilical vein puncture was performed in 14 cases whose MCA-PSV was significantly high.Results Among these 339 feruses there were patients with severe a-thalassemia.MCA-PSV in fetuses with severe a-thalassemia was significantly higher than in normal fetuses.The difference was statistically significant(P<0.001).Conclusions It is an effective way to forecast severe α-thalassemia by detecting MCA-PSV with ultrasonography.更多还原