【摘要】 目的评价流行病学研究的序贯筛选方法在早期胃癌检测中的应用。方法通过问卷调查,收回有效问卷9264份,填写问卷中的25项,每项根据程度记为0、1、2分。计分≤10分者停止研究;计分>10分者为低危险人群,进入实验室检测阶段。应用放射免疫法检测胃泌素、胃蛋白酶原Ⅰ/Ⅱ比值、癌胚抗原、糖类抗原72-4及巨噬细胞集落刺激因子等指标,其中≥1项阳性者为可疑人群,进入胃镜、病理或X线钡餐等进一步检查。结果回收的有效问卷中,计分>10分的710例,进行下一步研究,再根据问卷、血清学检测、胃镜及病理检查结果将710例筛查对象分为4组,仅问卷计分>10分的低危险人群组602例,占6498/10万;实验室检测1项阳性的可疑人群组82例,占885/10万;发现癌前病变者的高危险组20例,占216/10万;胃癌6例,占65/10万。结论通过流行病学调查,采用序贯筛选法是提高早期胃癌检出率的主要手段,适用于人群普查。更多还原

【Abstract】 Objective To enhance the detection rate of early gastric cancer through epidemiological methods of sequential screening. Methods The questionnaire method was adopted.A total of 9 264 valid questionnaires were regained.Each questionnaire containing 25 items was scored.Sequential screening was conducted based on the scores.The paper of score≤10 was excluded, and ones of score>10 went into the laboratory testing stage: gastrin,carcinoembryonic antigen,CA72-4,macrophage colony-stimulating factor and pepsinogenⅠ/Ⅱratio in serum were measured by radioimmunoassay,and suspicious population (at least 1 positive laboratory index) went into next step examination:endoscopy,pathology and barium meal for confirming diagnosis of precancerous lesion or gastric cancer.Results The population whose scores of questionnaire>10 were 710 persons,and among them,low-risk population group were 602 persons (6 498/105),suspicious population group 82 persons (885/105),high-risk population group (precancerous lesions) 20 persons(216/105) and gastric cancer 6 persons (65/105).Conclusions The epidemiological method of sequential screening is a major means to improve the detection rate of early gastric cancer.更多还原