【摘要】 目的:探讨细胞核增殖抗原(Ki67)及血管内皮生长因子(VEGF)在子宫腺肌症中在位和异位内膜的表达及意义。方法:用免疫组化EnVision法检测30例子宫腺肌症在位子宫内膜和肌间异位内膜Ki67和VEGF的表达情况。结果:Ki67和VEGF在子宫腺肌症病变中均有不同程度的阳性表达,子宫肌层异位内膜Ki67阳性表达率为53.3%,VEGF阳性表达率为96.7%。异位内膜的腺上皮Ki67和VEGF表达高于在位内膜的腺上皮(P<0.05)。腺上皮表达高于间质(P<0.05)。月经周期中VEGF的表达差异无统计学意义(P>0.05)。异位内膜腺体VEGF和Ki67的表达具有相关性(P<0.01)。结论:子宫腺肌症是一种细胞增殖性疾病。子宫腺肌症异位和在位子宫内膜组织中均有Ki67和VEGF的阳性表达,与子宫腺肌症的临床症状可能有关。更多还原

【Abstract】 Objective:To investigate the expressions of Ki67 and VEGF in the pathogenesis of adenomyosis uterus.Methods:The expressions of Ki67 and VEGF in 30 cases of adenomyosis uterus were detected by immunohistochemical EnVision method.Results:The positive rates of Ki67 and VEGF in ectopic endometrium of myometrium were 53.3% and 96.7%, respectively.The expressions of Ki67 and VEGF increased significantly in ectopic endometrium were slightly than those in eutopic endometrium(P<0.05).The strong positive rate in the eutopic endometrium was significantly higher than that in the stroma cells(P<0.05).In adenomyosis, no significant changes of VEGF expression was found throughout the menstrual cycle(P>0.05).The expression of VEGF had a positive correlation with the expression of Ki67(P<0.01).Conclusion:Adenomyosis is an endometrial proliferative disease.Ki67 and VEGF all express in the ectopic and eutopic endometrium. They may be play an important roles in clinical symptoms of adenomyosis.更多还原