【摘要】 目的:探讨Survivin及P53蛋白的表达在葡萄胎发生、发展及恶变中的作用。方法:采用免疫组织化学PV-6000法测定42例葡萄胎(其中12例恶变)和18例正常绒毛组织中p53和Survivin蛋白表达情况。结果:Survivin正常绒毛组和葡萄胎组的表达差异无统计学意义(P>0.05);p53在正常绒毛组和葡萄胎组表达差异具有统计学意义(P<0.05);Survivin及p53蛋白阳性表达率在葡萄胎恶变组中的表达均高于葡萄胎未恶变组(P<0.05)。结论:Survivin及p53可能与滋养细胞的侵袭过程及程度有关,检测葡萄胎组织中P53及Survivin的蛋白表达,可预测葡萄胎恶变,为临床预防性化疗提供一定的理论依据。更多还原

【Abstract】 Objective:To explore the expressions of Survivin and p53 and their effects on occurrence,development and malignant change of hydatidiform mole.Methods:The expressions of Survivin and p53 in 42 cases with hydatidiform mole(12 cases with malignant change) and 18 cases with normal villi were detected by immunohistochemical PV-6000 method.Results:There was no significant difference in Survivin expression level between normal villi group and hydatidiform mole group(P>0.05).There was significant difference in p53 expression level between normal villi group and hydatidiform mole group(P<0.05).The positive expression rates of Survivin and p53 in cases with malignant change of hydatidiform mole were significantly higher those in cases without malignant change of hydatidiform mole(P<0.05).Conclusion:Survivin and p53 may be related to invasion and degree of cytotrophoblast cells,detection of Survivin and p53 expressions in hydatidiform mole can predict malignant change of hydatidiform mole,and provide a theoretical basis for clinical preventive chemotherapy.更多还原