【摘要】 目的:探讨阴道局部细胞免疫功能状况与复发性外阴阴道假丝酵母菌病(RVVC)发病的关系。方法:选取2006年7月～2008年5月在广州市红十字会医院就诊及进行健康体检的育龄妇女,分为RVVC组(41例)、VVC组(38例)、对照组(38例)。留取阴道灌洗液,采用ELISA法检测其IFN-γ及IL-4浓度。结果:①阴道灌洗液中IFN-γ的表达水平RV-VC组与VVC组均明显高于对照组,RVVC组明显高于VVC组,差异具有统计学意义(P<0.05)。②阴道灌洗液中IL-4的表达水平RVVC组与VVC组均明显低于对照组,差异具有统计学意义(P<0.05);RVVC组与VVC组之间的差异没有统计学意义(P>0.05)。结论:阴道局部细胞免疫功能异常可能与外阴阴道假丝酵母菌病发病与复发有关。检测RVVC患者阴道灌洗液中的细胞因子,可以反映患者阴道局部细胞免疫状况,可作为对RVVC治疗监测的指标之一。更多还原

【Abstract】 Objective:To explore the relationship between immune function of vaginal local cells and pathogenesis of recurrent vulvovaginal candidiasis (RVVC).Methods:The women of child bearing age admitted to the hospital for treatment and physical examination from July 2006 to May 2008 were selected and divided into RVVC group (41 cases), VVC group (38 cases) and control group (38 cases); vaginal lavage fluids were collected to detect the levels of IFN-γ and IL-4 by ELISA.Results:The levels of IFN-γ in RVVC group and VVC group were significantly higher than that in control group.The level of IFN-γ in RVVC group was significantly higher than that in VVC group (P<0.05).The levels of IL-4 in RVVC group and VVC group were significantly lower than that in control group (P<0.05).There was no significant difference between RVVC group and VVC group (P>0.05).Conclusion:The abnormality of immune function of vaginal local cells may be related to pathogenesis and recurrence of RVVC; detection of cytokines in vaginal lavage fluids of patients with RVVC can reflect the immune condition of vaginal local cells, which can be used as a monitoring indication of RVVC treatment.更多还原