【摘要】 目的:研究布地奈德气雾剂吸入治疗对支气管哮喘患儿外周血神经生长因子(NGF)水平的影响。方法:选择门诊支气管哮喘患儿52例分为两组,所有病例均在发作缓解期检测外周血神经生长因子及肺功能(FEV1),研究组36例为布地奈德气雾剂吸入治疗组,按06版GINA方案给予布地奈德气雾剂分级吸入预防治疗,对照组16例根据自愿原则未进行布地奈德气雾剂吸入治疗,3个月后再次检测所有患儿外周血神经生长因子水平及肺功能。结果:研究开始前两组患儿血清神经生长因子水平分别为(85.8±21.2)pg/ml和(66.4±15.6)pg/ml,3个月后布地奈德气雾剂吸入治疗组患儿血清神经生长因子浓度降为(45.6±12.2)pg/ml,与研究前差异具有统计学意义(P<0.001),同时FEV1明显提高(P<0.001),而未吸入激素治疗的患儿血清神经生长因子水平为(68.9±14.2)pg/ml,与研究开始前差异无统计学意义(P>0.05),FEV1未显示明显提高(P>0.05)。结论:布地奈德气雾剂吸入治疗能降低支气管哮喘患儿外周血神经生长因子水平。更多还原

【Abstract】 Objective:To investigate the effect of budesonide inhalation on nerve growth factor(NGF) level in peripheral blood of children with asthma.Methods:52 children with asthma were selected and divided into two groups,NGF level in peripheral blood and pulmonary function(FEV1) of all the cases were detected during remission stage of asthma;36 children in treatment group were treated with budesonide inhalation according to 06 GINA project,16 children in control group didn’t receive budesonide inhalation,NGF level in peripheral blood and pulmonary function(FEV1) of all the cases were detected after three months.Results:Before treatment,the serum levels of NGF in peripheral blood in the two groups were(85.8±21.2) pg/ml and(66.4±15.6) pg/ml,respectively,after three months,the serum level of NGF in peripheral blood of treatment decreased to(45.6±12.2) pg/ml,there was significant difference before and after treatment(P<0.001),at the same time,FEV1 increased significantly(P<0.001),after three months,the serum level of NGF in peripheral blood of control group was(68.9±14.2) pg/ml,there was no significant difference before and after treatment(P>0.05),the increase of FEV1 was no significantly(P>0.05).Conclusion:Budesonide inhalation can reduce the level of NGF in peripheral blood of children with asthma.更多还原