【摘要】 目的:探讨复发性流产与抗心磷脂抗体(ACA)和抗精子抗体(ASA)之间的相关性。方法:用ELISA法检测122例复发性流产患者(观察组)的ACA及ASA-Ig,选择155例不孕症妇女和35例无流产史且已分娩活胎的健康妇女作为对照组,应用强的松、阿司匹林治疗抗磷脂抗体所致的凝血功能异常。结果:观察组ACA阳性检出率与不孕症和正常妇女组相比,差异有统计学意义(P(0.05),两对照组之间差异无统计学意义;观察组ASA-Ig阳性检出率明显高于两对照组(P(0.05),不孕症组明显高于正常妇女组(P(0.05)。ACA经过治疗后的继续妊娠率是76.1%。结论:复发性流产与ACA和ASA关系密切,抗磷脂抗体综合征是RSA的重要原因之一;阿司匹林治疗ACA导致的复发性流产疗效确切。更多还原

【Abstract】 Objective:To study relationship between recurrent spontaneous abortion(RSA) and anticardiolipin antibodies and anti-sperm antibody.Methods:The levels of serum ACA and ASA-Ig in 122 recurrent spontaneous abortion women and 155 infertility women and 35 normal women were determined by the enzyme linked immunoabsorbent assay, hormone and aspirin were used block abnormal coagulation function caused by anticardiolipin antibody.Results:The positive rate of ACA and ASA-Ig in RSA women was significantly higher than that in the control groups(P﹤0.05). The positive rate of ACA was not significantly different between infertility and normal women.The positive rate of ASA-Ig infertility group was significantly higher than normal.Conclusion:There is a close correlation between recurrent spontaneous abortion(RSA) and anticardiolipin antibodies and anti-sperm antibody,APA is one of the important cause of RSA.更多还原