【摘要】 目的:探讨全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)对早产儿凝血功能的影响。方法:本院新生儿病房在2004年1月～2006年1月收治合并SIRS早产儿65例和未合并SIRS早产儿45例检测凝血因子Ⅰ、Ⅱ、Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅹ、Ⅻ及PT、APTT、TT、DD、PLT并进行比较。结果:两组早产儿的检测结果在统计学上具有显着性差异,P<0.05。结论:感染性和非感染性因素可活化炎症细胞产生炎症介质进一步活化炎症细胞,引起炎症自我放大的级联反应和损伤,同时激活凝血系统,凝血过程中生成的多种凝血因子反过来又促进炎症反应的发生,凝血系统的激活和炎症反应相互促进、相互影响,早产儿的凝血与止血在一个低水平维持平衡,更容易发生凝血功能紊乱,病因治疗对获得性出血十分重要。更多还原

【Abstract】 Objective:To explore the effect of systemic inflammatory response syndrome (SIRS) on coagulation function of premature infants.Methods:Levels of coagulation factors Ⅰ,Ⅱ,Ⅴ,Ⅶ,Ⅷ,Ⅸ,Ⅹ,Ⅻ and prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),DD,platelet count (PLT) were detected from January 2004 to January 2006 in 65 premature infants with SIRS and 45 premature infants without SIRS,then the results were compared.Results:There was significant difference in test results between the two groups (P<0.05).Conclusion:Infectious factors and non-infectious factors activate inflammatory cells,produce inflammatory mediators,which can activate inflammatory cells further,inflammatory cascade and lesions are induced and coagulation system is activated,coagulation factors promote inflammatory reaction,the premature infants keep a reduced level balance of coagulation and hemostasia,and etiological treatment is important for acquired bleeding.更多还原