【摘要】 目的探讨肝硬化患者血清胰岛素生长因子1(IGF-1)与肝功能损害程度之间的关系。方法检测61例肝硬化患者和30例正常对照组血清IGF-1和肝功能指标胆红素(TBIL)、总胆汁酸(TBA)、胆碱酯酶(CHE)、白蛋白(ALB)水平,并按child-pugh分级法分为A、B、C三组。结果肝硬化患者血清IGF-1、CHE、ALB明显低于正常对照组(P<0.05);随child-pugh积分增高而降低,呈负相关。TBA、TBIL显著高于对照组(P<0.05),与分级呈正相关。结论血清IGF-1是反应肝硬化患者肝功能损害的一个良好指标。更多还原

【Abstract】 objective To evaluate of the relationship between the serum IGF-1 Level and the hepatic functional lesion in liver cirrhosis.Methods All 61 cases of liver cirrhosis were divided into three groups according to child-pugh classification.The serum IGF-I,TBIL,TBA,CHE and ALB were detected in the three groups.Results The serum IGF-1,CHE and ALB levels in liver cirrhosis were significantly lower than thoseinthecontrolgroup [mean(,88.75±44.35)μg/mL versu(s253.18±67.73)μg/mL,(2378.8±855.1)U/Lversu(s7212.1±756.3)U/L,(30.78± 5.78)g/Lversus(47.5±5.3)g/L respectively],where as TBA and TBIL levels were significantly higher than those of the controls [mean(,56.6± 15.3)μmol/L versus(5.5±2.1)μmol/L,(61.3±8.9)μmol/L versus(16.7±2.4)μmol/L respectively].All levels of the serum markers were correlated with child score.Conclusion IGF-1 can represent a good marker of hepatic function lesion in liver cirrhosis.更多还原