【摘要】 目的探讨腹腔钙化性纤维性肿瘤(CFT)的临床病理特征和免疫组化表型。方法分析2例腹腔CFT的临床资料、病理学形态、免疫组化和特染结果。结果 2例患者为母女关系,例1(女儿)20岁时因肠穿孔手术发现CFT,13年后再次手术;例2(母亲)因胃癌手术发现CFT。肿物位于胃壁、肠壁、大网膜、肠系膜及子宫,肿瘤体积最大的位于子宫,直径为6cm,其余均<2.5cm,质坚硬,无包膜。镜检:肿瘤由大量胶原纤维组成,成纤维细胞少;间质内小淋巴细胞集聚,并形成初级滤泡,血管周围浆细胞浸润;肿瘤伴有不同程度的砂砾体、钙化及骨化。免疫组化显示梭形细胞vimentin、CD10(+),SMA、actin、S-100、desmin、p63、CK、CD34、CD21、CD117和CD1a(-);子宫的CFT梭形细胞CD34弥漫(+)。结论腹腔CFT的病理形态及免疫表型与腹腔外的无差别,家族性与非家族性无差别。CFT虽有侵袭性表现,但预后良好。CD34阳性的CFT是否预示肿瘤具有侵袭性或早期改变有待进一步研究。更多还原

【Abstract】 Objective To study the clinicopathologic and immunohistochemical features of calcifying fibrous tumor (CFT). Methods The clinical,pathologic and immunohistochemical features were reevaluated in two cases of CFT. Results Two cases had mother-daughter relationship. One tumor occurred in a 20-year-old girl and was found during abdominal operation for intestinal perforation. Whereas the other tumor occurred in her mother,a 61-year-old woman and was found during abdominal operation of gastric carcinoma. The tumors located in the gastric and intestinal wall,greater omentum,mesentery and uterus. The biggest one,6 cm in diameter,was located in uterus. The others were hard,less than 2. 5cm in diameter,without capsule. Mirocospically,the tumor was composed of abundant bundles of hyalinized collagens interspersed with fibroblast -like spindle cells. All 2 cases were characterized by deposition of dystrophic or psammatous calcifications accompanied with chronic inflammatory cells infiltration and the formation of germinal centers in the stroma. Immunohistochemically,the spindle cells were positive for VIM and CD10 but negative for SMA,actin,desmin,P63,CK,CD34,CD21,CD117,and CD1a. The spindle cells were diffusely positive for CD34 in the tumor in uterus. Conclusion The pathological morphology and immunophenotype of CFT have no difference within and outside the abdominal cavity as well as familial and non-familial type. CFT has invasive nature,but the prognosis is good. Whether CD34 + predicates more invasive and earlier stage of CFT or not needs further study.更多还原