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栀子中的木脂素类成分研究

A new lignan from Gardenia jasminoides

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【作者】 于洋高昊戴毅李小霞李嘉明姚新生

【Author】 YU Yang1,GAO Hao1,2,DAI Yi1,2,LI Xiao-xia2,LI Jia-ming2,YAO Xin-sheng1,2,3(1. College of Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China; 2. Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China; 3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents TCM and New Drugs Research,Jinan University,Guangzhou 510632,China)

【机构】 沈阳药科大学中药学院暨南大学药学院中药及天然药物研究所暨南大学中药药效物质基础及创新药物研究广东省重点实验室

【摘要】 目的研究栀子Gardenia jasminoides果实60%乙醇提取物的化学成分。方法采用各种现代色谱技术进行分离和纯化,根据化合物的光谱数据进行结构鉴定。结果分离鉴定了12个木脂素类化合物,其结构分别为栀子脂素甲(1)、丁香脂素(2)、松脂素(3)、丁香脂素-4-O-β-D-吡喃葡萄糖苷(4)、落叶松脂素(5)、八角枫木脂苷D(alangilignosideD,6)、落叶脂素(7)、落叶脂素-9-O-β-D-吡喃葡萄糖苷(8)、蛇菰宁(balanophonin,9)、山橘脂酸(10)、榕醛(ficusal,11)、肥牛木素(12)。结论化合物1为一新化合物,命名为栀子脂素甲,化合物2~6、9~12为首次从该属中分离得到。

【Abstract】 Objective To study the chemical constituents in 60% ethanol extract from the fruit of Gardenia jasminoides. Methods The compounds were isolated by various chromatographic techniques and identified by spectroscopic methods. Results Twelve compounds were obtained and identified as gar-denianan A (1),syringaresinol (2),pinoresinol (3),syringaresinol-4-O-β-D-glucopyranoside (4),lariciresinol (5),alangilignoside D (6),lyoniresinol (7),lyoniresinol-9-O-β-D-glucopyranoside (8),balanophonin (9),glycosmisic acid (10),ficusal (11),and ceplignan (12). Conclusion Compound 1 is a new compound named gardenianan A. Compounds 2-6 and 9-12 are reported for the first isolation from the plants of Gardenia Ellis.

【关键词】 栀子木脂素栀子脂素甲
【Key words】 Gardenia jasminoides Ellislignansgardenianan A
【基金】 国家自然科学基金项目(30701047);教育部科学技术研究重点项目(208173)
  • 【文献出处】 中草药 ,Chinese Traditional and Herbal Drugs , 编辑部邮箱 ,2010年04期
  • 【分类号】R284.1
  • 【被引频次】84
  • 【下载频次】1459
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