【摘要】 <正>α-突触核蛋白(α-synuclein)是一种脑内含量丰富的神经蛋白,既参与正常突触功能的维持,又与各种神经退行性疾病有关。在帕金森病(Parkinson’更多还原

【Abstract】 α-Synuclein is identified as a constant component of dopaminergic neuronal pale eosinophilic inclusions"the Lewy bodies"in Parkinson’s disease. In fact,normal α-synuclein has lots of biological functions,which regulates synaptic plasticity,integrates presynaptic signaling,regulates dopamine level in the synapse,modulates microglial activation and lipid metabolism,and exerts heat shock protein-like function. However,abnormal α-synuclein leads to pathological lesion. Many studies show that pathological α-synuclein levels are elevated under the condition of its gene mutation,certain posttranslational modifications,dysfunction of molecular chaperones or ubiquitin proteasome system. The pathological α-synuclein plays an important role in neurodegeneration,in particular,Parkinson’s disease because it interrupts integrity of synaptic vesicles,ER-Golgi traffic and axonal transport,inhibits histone acetylation and chaperone-mediated autophagy,stabilizes itself against proteasomal degradation,and leads to neuroinflammation and abnormal phosphorylation of tau.更多还原