【摘要】 目的观察阿维A联合他扎罗汀治疗原发性皮肤淀粉样变病的疗效。方法 45例原发性皮肤淀粉样变病患者随机分为两组。治疗组(24例)和对照组(21例)均给予阿维A30mg/d,分3次服用,连续服用4周,改为20mg/d,分2次服用,再服用4周,最后改为10mg/d维持治疗,连用4周,治疗组同时联合外用他扎罗汀,每晚使用1次。两组还同时使用依巴斯汀10mg/d口服、卤米松乳膏每天外用1次。结果疗程结束后治疗组和对照组的有效率分别为70.83%和28.57%,差异有显著性(P<0.05)。结论阿维A联合他扎罗汀治疗原发性皮肤淀粉样变的疗效优于单用阿维A治疗。更多还原

【Abstract】 Objective To evaluate the efficacy of acitretin combined with tazarotene in the treatment of primary cutaneous amyloidosis.Methods Fouty-five cases with primary cutaneous amyloidosis were divided into two groups randomly.Patients in the treatment group and the control group were given acitretin 10 mg three times daily for 4 weeks.Then,the dosage was reduced to 10 mg twice daily for 4 weeks.Finally,the dosage was 10mg once daily for 4 weeks.At the same time,patients in the treatment group were given topical tazarotene once nightly.All patients were given oral ebastine 10 mg once daily and topical halometasone cream once daily.Results At the end of treatment,the effective rates were 70.83% and 28.57% respectively.There was significant difference between the treatment group and the control(P<0.05).Conclusion Acitretin combined with tazarotene is more effective than acitretin alone in the treatment of primary cutaneous amyloidosis.更多还原