【摘要】 目的了解急性泛发性发疹性脓疱病(AGEP)的致病药物、治疗和转归,以提高临床医师对药物引起AGEP的认识。方法收集近9年23例AGEP病例资料,进行回顾性分析。结果引起AGEP的药物主要有抗菌药占73.9%(17/23),其中β-内酰胺类占30.4%(7/23),林可胺类占26.1%(6/23),大环内酯类占8.7%(2/23),喹诺酮类占8.7%(2/23),其他有解热镇痛抗炎药、感冒药、中(成)药等。治疗均给予糖皮质激素,约相当于泼尼松1mg/(kg.d)。1～4天后体温恢复正常,皮疹消退时间5～10天。结论药物是AGEP的主要病因,致病药物主要是抗菌药。分次给予中小剂量糖皮质激素,可能较为合理。更多还原

【Abstract】 Objective To study the causes,clinical features,treatment and prognosis of acute generalized exanthematous pustulosis induced by drugs.Methods A retrospective analysis was carried out based on the clinical data of 23 patients with acute generalized exanthematous pustulosis in our hospital from Jan 2000 to Dec 2008.Results The drugs most often responsible for acute generalized exanthematous pustulosis were antibacterial agent (73.9%,17/23),especially the β-lactam antibiotics (30.4%,7/23),lincosamide (26.1%,6/23),macrolides (8.7%,2/23),and quinolones (8.7%,2/23),followed by the antipyretic analgesics,Chinese medicine.All cases were cured and effected to glucocorticosteroid.Conclusion Drugs,especially antibacterial agent are the most frequent causes of acute generalized exanthematous pustulosis.Administering with lower or medium dose of glucocorticosteroid is the key in the treatment of acute generalized exanthematous pustulosis.更多还原