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芝麻素对高脂血症大鼠糖代谢的作用

EFFECT OF SESAMIN ON GLUCOSE METABOLISM IN HYPERLIPIDEMIA RATS

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【作者】 安建博张瑞娟周玲

【Author】 AN Jian-bo,ZHANG Rui-juan1,ZHOU Ling1 (Xi’an Center for Disease Control and Prevention,Xi’an 710054,China; 1 Department of Public Health,Medical School of Xi’an Jiaotong University,Xi’an 710061,China)

【机构】 西安市疾病预防控制中心西安交通大学医学院公共卫生学系

【摘要】 目的探讨芝麻素对高脂血症大鼠糖代谢的作用。方法选择SD大鼠,喂饲高脂饲料,建立高脂血症大鼠模型。然后对高脂模型大鼠进行芝麻素干预7w后,检测各组大鼠的血脂、空腹血糖(FBS)、糖化血红蛋白(HbA1c)、血清胰岛素等水平以及观察大鼠胰腺组织的病理学变化。结果芝麻素可以降低高脂血症大鼠血清TC、TG、LDL-C及apoB水平,适当升高HDL-C和apoA的含量(P<0.05);降低高脂血症大鼠血清胰岛素水平、调节脂代谢紊乱下的血糖水平,改善机体对胰岛素的敏感性(P<0.05);抑制高脂血症大鼠胰腺胰岛素和生长抑素的分泌水平。结论芝麻素可以调节高脂血症大鼠脂代谢紊乱下的糖代谢,改善高脂血症时机体的胰岛素抵抗(IR)状态。

【Abstract】 Objective To study the effect of sesamin on glucose metabolism in hyperlipidemia rats. Method The hyperlipidemia SD rats were established by high lipid diet. These rats were intervened by sesamin for 7 w,and then their serum lipids were determined. Fasting blood glucose (FBS),glycosylated hemoglobin (HbA1c),insulin,and the pathological changes of pancreas were observed. Results Sesamin could reduce serum TC,TG,LDL-C,apoB and insulin levels,appropriately increase HDL-C and apoA contents (P<0.05) in hyperlipidemic rats. Sesamin could regulate blood sugar levels,inhibit pancreatic insulin and somatostatin levels,and improve the body’s insulin sensitivity (P<0.05). Conclusion Sesamin could regulate glucose metabolism and improve insulin resistance status caused by hyperlipidemia.

【关键词】 芝麻素高脂血症糖代谢大鼠
【Key words】 glucose metabolismhyperlipidemiaratssesamin
  • 【文献出处】 营养学报 ,Acta Nutrimenta Sinica , 编辑部邮箱 ,2010年02期
  • 【分类号】R589.2;R587.1
  • 【被引频次】5
  • 【下载频次】241
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