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葛根素对大鼠脑缺血/再灌注损伤缺血区细胞粘附分子ICAM-1的影响

Effects of Puerarin on Intercellular Adhesion Molecule-1 in Rats with Cerebral Ischemia/Reperfusion Injury

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【作者】 涂强林捷谭小平马兰成祥林朱遂强

【Author】 TU Qiang,LIN Jie,TAN Xiao-ping,et al.The First Affiliated Hospital of Yangtze University of Medicine,Hubei,434002,China

【机构】 长江大学医学院附属第一医院荆州市第三人民医院华中科技大学附属同济医院

【摘要】 目的探讨葛根素对大鼠脑缺血/再灌注损伤缺血区细胞粘附分子ICAM-1的影响。方法采用模拟临床上缺血性卒中的大鼠中脑动脉阻塞局灶性脑缺血/再灌注模型,预先给予葛根素腹腔注射7d后,运用免疫组织化学方法 ,检测大鼠脑缺血/再灌注损伤脑组织中ICAM-1蛋白的表达。结果葛根素能明显降低脑组织缺血区血管内皮细胞ICAM-1蛋白的表达,与模型组相比差异有统计学意义(P<0.01)。结论葛根素能明显抑制大鼠局灶性脑缺血/再灌注所致炎症反应,对大鼠脑缺血-再灌注造成的脑血管内皮损伤具有明显保护作用。

【Abstract】 Objective Discuss the effect of puerarin on ICAM-1 in rats with cerebral ischemia/reperfusion injury.Methods Establishment of rat model of middle cerebral artery occlusion-induced focal cerebral ischemia/reperfusion injury.Rats were pretreated with intraperitoneal injection of puerarin for 7 days,and then immunohistochemistry was used to detect the expression of ICAM-1 in brain tissue.Results Puerarin can significantly reduced expression of ICAM-1 in vascular endothelial cells,the differences was statistically significant (P<0.01).Conclusion Puerarin can inhibit inflammation induced by focal cerebral ischemia/reperfusion and has the protective effect on cerebral vascular endothelial injury.

  • 【文献出处】 慢性病学杂志 ,Chronic Pathematology Journal , 编辑部邮箱 ,2010年08期
  • 【分类号】R285.5
  • 【被引频次】11
  • 【下载频次】215
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