【摘要】 目的观察褪黑素(MEL)对5/6肾切除大鼠残肾炎症反应的抑制作用,探讨其治疗慢性肾衰竭的作用机制。方法建立5/6肾切除大鼠慢性肾衰竭模型。分为假手术(CTL)组、5/6肾切除(STN)组和MEL组,各48只。MEL组灌胃给予MEL5mg·kg-1.d-1,共40周。检测第1,2,4,8,12,16,26和40周共8个不同的时间段单核巨噬细胞浸润的情况。结果 5/6肾切除大鼠残肾肾间质炎性浸润指数显著升高。与STN组比较,MEL组尿蛋白排泄量和间质炎性细胞浸润均显著减少(P<0.05或P<0.01)。结论 MEL能够减少5/6肾切除大鼠尿蛋白排泄量,抑制肾间质炎性细胞的浸润,保护肾功能。更多还原

【Abstract】 Objective To study the effects of long-term administration of melatonin(MEL)on inflammation in subtotally nephrectomized rats and to explore the mechanism.Methods Established a model of subtotal(5/6)nephrectomy(STN)and took melatonin(5 mg·kg-1·d-1)for 40 weeks.The changes of inflammatory cells infiltration(ED-1)at the 1st,2nd,4th,8th,12th,16th,26th and 40th week after operation were detected.Results The indexs of infiltration of inflammatory cells increased on the remnant kidney in STN group,which were lessened in renal interstitiun remarkably(P<0.05,P<0.01)in MEL group.Conclusion Melatonin has therapeutic effects on inhibiting inflammtion in interstitium by reducing urinary protein excretion.更多还原