【摘要】 二甲基甲酰胺(DMF)属中等毒类物质,DMF对消化系统损害的机制至今尚未完全阐明。DMF被吸入机体后对胃黏膜造成不同程度的损害,出血性胃肠炎为DMF中毒较突出的表现。乙醇引起的胃黏膜急慢性损伤已经明确。乙醇除直接损伤胃黏膜外,还可通过增强胃黏膜损伤因素、削弱胃黏膜保护因素和使细胞内钙超载等机制引起胃黏膜损伤。乙醇对胃黏膜的影响较为复杂,深入研究其对胃黏膜的作用机制,对于胃黏膜保护有积极意义。DMF与乙醇对胃黏膜毒性的协同作用有待于进一步深入研究。更多还原

【Abstract】 Dimethylformamide(DMF)was belong to middling toxicity,the digestive system damage of DMF mechanism has not yet been fully elucidated.After DMF was absorpted organism,gastric mucosa was caused varying degrees of damage,hemorrhagic gastroenteritis was the more prominent performance of DMF poisoning.Acute and chronic gastric mucosal injury caused by ethanol has been clear.In addition to direct damage to gastric mucosa,ethanol can also induce gastric mucosal injury by enhancing the gastric mucosal injury factors,weakening the gastric mucosal protective factors and overloading intracellular calcium.The impact of ethanol on gastric mucosa was more complex,in-depth study of its action mechanism has a positive meaning to protect gastric mucosa.The synergies of DMF and ethanol on the gastric mucosal toxicity was be further study.更多还原