【摘要】 细菌脂多糖(LPS)或细菌内毒素能引起内毒素血症、脓毒症等疾病。近年来,有关LPS的研究备受关注,LPS在机体细胞内的作用机制为研究重点。研究表明,LPS与细胞膜上相应受体作用后,启动胞内信号传递链,引起核因子κB等活化,启动基因转录,表达和释放多种细胞因子,发挥其毒性作用。而微量的LPS能够活化单核巨噬细胞系统,促进细胞因子释放,促进补体的活化和抗体的产生,对特异性免疫反应具有调节作用。更多还原

【Abstract】 Bacterial lipopolysaccharide(LPS)or bacterial endotoxin,can cause endotoxemia,sepsis and other diseases.Researches in recent years have drawn greater attention to LPS.LPS in the intracellular mechanisms were the research emphasis.Studies have shown that LPS can start intracellular signal transduction chain and cause nuclear transcription factor κB and so on activation after effecting with the corresponding receptors on the cell membrane,and switch on gene transcription,express and release a variety of cytokines,play toxic effects of LPS.The small amount of LPS can activate monocyte-macrophage system,promote the release of cytokines,complement activation and antibody production,had the role of regulating specific immune response.更多还原