【摘要】 目的探讨健脾化瘀解毒复方胃痞汤对慢性萎缩性胃炎(CAG)模型大鼠胃黏膜上皮细胞病理改变的影响。方法采用致癌化学物质N-甲基-N′-硝基-N压硝基胍配合饥饱失常、耗气泻下法建立CAG脾虚模型。采用免疫组化法检测胃黏膜萎缩、肠上皮化生等病理变化。结果模型对照组胃黏膜萎缩、肠上皮化生均较正常组明显增加(P<0.01):胃痞汤预防组、高、中、低剂量组较模型对照组明显降低(均P<0.01)。结论胃痞汤防治CAG的作用机制与其通过降低胃黏膜萎缩,肠上皮化生有关,对萎缩发生有一定的治疗作用。更多还原

【Abstract】 Objective To explore the effect of weipitang,a compound of invigorating spleen and removing blood statis and toxic substance,on pathologic changes of gastric mucosal cells of chronic atrophic gastritis(CAG).Methods CAG model with syndrome of spleen deficiency was established by N-methyl-N’-nito-N-nitrosoguanidine(MNNG)and irregular fasting combined with purgative drugs.Changes of gastric mucous atrophy and intestinal metaplasia in gastric mucous were observed with HE technique and immunohistochemical stain.Results Gastric mucous atrophy and intestinal metaplasia in gastic mucous of the model group were more obvious than those of the normal group(P<0.01);but decreased in the three different dosage of Weipitang groups(P<0.01).Conclusion The mechanism of weipitang in preventing CAG may be reducing gastric atrophy and intestinal metaplasia.Weipitang has some therapeutic effect on CAG.更多还原