【摘要】 目的探讨邻苯二甲酸二丁酯(DBP)对不同组织器官的氧化损伤作用及其分子机制。方法用0μmol/L、5μmol/L、20μmol/L、80μmol/L的DBP溶液对大鼠4种脏器(肝脏、肺、睾丸、肾脏)细胞进行体外染毒1h,测定染毒后几种脏器细胞中超氧化物歧化酶(SOD)的水平。结果随着DBP染毒浓度的升高,大鼠各脏器细胞中SOD酶活性下降,且在5μmol/L浓度时就与对照组的差异具有良好的统计学意义(P<0.01)。结论 DBP能够对体外大鼠4种脏器(肝脏、肺、肾脏、睾丸)细胞造成以SOD抑制为特征的氧化损伤。更多还原

【Abstract】 Objective The present study was conducted to study the oxidation damage effects of DBP on organs of mice and the molecular mechanisms of the effects. Methods The cells of the organs (liver,kidney,testis,lung) were exposed to different concentration of DBP (0μmol/L,5μmol/L,20μmol/L,80μmol/L) for one hour in vitro,and then the superoxide dismutase (SOD) activities of those cells of different organs were measured. Results With statistical significance,the SOD activities in liver,kidney,testis,lung cells were increased gradually with the increase of DBP concentrations. Conclusion The results suggested that DBP could induce the oxidative damage in liver,lung,kidney and testis cells of mice.更多还原