【摘要】 目的探讨肿瘤坏死因子TNFα-238G/A基因多态性与子宫内膜异位症的关系。方法运用聚合酶链反应技术检测200例子宫内膜异位症及200例正常人肿瘤坏死因子TNFα-238G/A基因多态性。结果子宫内膜异位症组TNFα-238G/A、G/G、A/A表型频率分别为:0.9300、0.070、0,对照组分别为:0.9500、0.0500、0;子宫内膜异位症组TNFα-238G、TNFα-238A基因频率分别为:0.9650、0.0350,对照组分别为:0.9750、0.0250,肿瘤坏死因子TNFα-238G/A各种基因型频率在患者组与正常对照组之间的差异无统计学意义(P>0.05)。结论肿瘤坏死因子TNFα-238G/A基因多态性与子宫内膜异位症无明显相关。更多还原

【Abstract】 Objective To investigate the relationship between tumor necrosis factor(TNF)-238G/A polymorphism and endometriosis. Methods The polymorphism of TNF α-238G/A gene was screened by PCR-RELP. Results The gene frequency of TNFα-238G/A in endometriosis group was as followed:TNF α-238G/A,G/G,A/A genotype frequency:0.9300,0.070,0; TNFα-238 G,TNFα-238 A genefrequency:0.9650,0.0350. The gene frequency of TNFα-238G/A in control group was as followed:TNFα-238G/G,G/A,A/A genotype frequency:0.9500,0.050,0,TNFα-238 G,TNFα-238 A genefrequency:0.9750,0.0250,There were no significant differences in the frequencies of TNFα-238G/A gene between the patients and control group (P>0.05). Conclusion No evident association was found between TNFα-238G/A polymorphism and endometriosis.更多还原