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壳聚糖化学改性及其衍生物在医药领域的应用进展

Chemical Modification of Chitosan and Application of its Derivatives in Medical Fields

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【作者】 李东华王鸿颜剑波熊文说易喻梅建凤应国清

【Author】 Li DongHua1,Wang Hong1,Yan JianBo2,Xiong WenYue1,Yi Yu1,Mei JianFeng1,Ying GuoQing1* (1.School of Pharmacy,Zhejiang University of Technolrgy,Hangzhou 310014,China; 2.Zhejiang New-Dankong Pharmaceutical Co.,LTD,Taizhou 318000,China)

【机构】 浙江工业大学药学院浙江新东港药业股份有限公司

【摘要】 壳聚糖因活泼基团氨基和羟基的存在,可以引入不同基团进行化学改性,生成的多种不同衍生物因具有良好的生物相容性、生物降解性、吸湿保湿性等特点,被广泛地应用于医药领域。就近年来壳聚糖常见的几种化学改性方法及其衍生物在医药领域的应用进展进行综述。

【Abstract】 Different groups of chitosan could be introduced for chemical modification to generate various derivatives due to the existence of active amino and hydroxyl group. Further more,the derivatives has a number of unique properties such as biocompatibility,biodegradability,moisture-absorption and moisture-retention abilities and so on,which enable them to have wide application in medical fields. In this aticle,some correlative literatures of both inside and outside country was summarized to review the progress in chemical modification of chitosan,and application of its derivatives in medical fields recently.

【关键词】 壳聚糖化学改性衍生物医药综述
【Key words】 ChitosanChemical ModificationDerivativesMedicineApplication
  • 【文献出处】 亚太传统医药 ,Asia-Pacific Traditional Medicine , 编辑部邮箱 ,2010年04期
  • 【分类号】R318.08
  • 【被引频次】8
  • 【下载频次】767
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