【摘要】 目的观察维生素E对慢性肾功能衰竭患者肾纤维化的影响。方法将74例慢性肾功能衰竭患者随机分为2组,对照组37例按常规治疗,治疗组37例在常规治疗基础上加用维生素E,治疗3个月后观察2组血清肌酐(Scr)、尿素氮(BUN)、内生肌酐清除率(Ccr)和层黏连蛋白(LN)、透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)等指标的的改变情况。结果与治疗前比较,2组血清Scr、BUN、LN、HA、PC-Ⅲ、Ⅳ-C水平均降低,Ccr均提高,且除LN外,治疗组各项指标均优于对照组,差异有统计学意义(P<0.05)。结论维生素E能抑制肾纤维化,延缓慢性肾功能衰竭的进程。更多还原

【Abstract】 Objective To study the effect of vitamin E on renal fibrosis in chronic renal failure(CRF) patients. Methods 74 patients were screened and randomly divided into two groups:treatment group and control group.In control group,37 cases were treated by conventional treatment,and the cases in treatment group(n=37) were added vitamin E beyond conventional therapy.Then serum creatinine(Scr),blood urea nitrogen(BUN),endo genous creatinine clearance rate(Ccr) and laminin(LN).hyaluronic acid(HA),Ⅲprocollagen(PC-Ⅲ),Ⅳcollagen (Ⅳ-C) were detected.Results Compared with those before treatment,Scr,BUN,LN,HA,PC-Ⅲ,Ⅳ-C were significantly lowered in both groups,and Ccr increased,treatment group were obviously better than those of control group except LN(P<0.05).Conclusion Vitamin E could suppress renal fibrosis,and delay the chronic renal fai lure process.更多还原