【摘要】 目的:观察西洛他唑对小鼠慢性缺血性脑损伤的保护作用,探讨其与促血管生成的关系。方法:以大脑中动脉栓塞方法诱导小鼠局灶性脑缺血,缺血后1、4、7 h和术后1～14 d腹腔注射西洛他唑(10 mg/kg),每天一次,观察缺血后35 d西洛他唑对神经症状评分、斜板角度、脑梗死体积、神经元密度和缺血侧血管内皮生长因子(VEGF)、血管内皮生长因子受体2(Flk-1)表达的作用。结果:西洛他唑能降低缺血后神经症状评分,提高斜板角度,减少脑梗死体积,增加存活神经元密度和VEGF、Flk-1表达的数目。结论:西洛他唑对小鼠慢性局灶性脑缺血具有保护作用,其作用机制可能与诱导缺血侧VEGF、Flk-1表达,促进血管生成有关。更多还原

【Abstract】 AIM:To observe the protective effects of cilostazol on chronic ischemic brain injury in mice and the relationship to angiogenesis.METHODS: Focal cerebral ischemia was induced by middle cerebral artery occlusion(MCAO).Cilostazol(10 mg/kg) was i.p.injected at 1,4,7 h and 1-14 d once a day after ischemia.The neurological deficits,angle in inclined board test,infarct volume,neuron density,and the expressions of VEGF and Flk-1 in ischemic region were determined at the 35 d after ischemia.RESULTS: Cilostazol(10 mg/kg) significantly reduced the neurological deficits and infarct volume,and increased the angle in inclined board test,the neuron density,and the expressions of VEGF and Flk-1.CONCLUSION: Cilostazol has neuroprotective effect on chronic ischemic brain injury in mice,which may relate to angiogenesis via inducing the expressions of VEGF and Flk-1.更多还原