【摘要】 目的探讨碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)和血管内皮生长因子(Vascular epithelial growthfactor,VEGF)在甲状腺微小癌中的表达及意义。方法用免疫组织化学S-P方法检测34例甲状腺微小癌、30例甲状腺分化型乳头状癌和20例甲状腺腺瘤性增生中bFGF和VEGF的表达情况,并进行比较。结果 bFGF和VEGF表达阳性率在甲状腺微小癌、分化型乳头状癌和腺瘤性增生中分别是70%、50%、15%和75%、50%、、5%,癌旁正常甲状腺组织阴性。经两两比较,甲状腺微小癌和分化型乳头状癌中bFGF和VEGF的表达无统计学差异,与癌旁甲状腺组织和甲状腺腺瘤性增生有显著差异。结论检测甲状腺微小癌组织中VEGF、bFGF的表达可作为临床辅助诊断、评价甲状腺乳头状癌生物学行为的参考指标,甲状腺微小癌和分化型乳头状癌一样有恶性行为及局部淋巴结转移的倾向。更多还原

【Abstract】 Objective To study the expression of bFGF and VEGF in thyroid micro carcinomas. Methods Immunohistochemical SP technique was used to determined the expression of bFGF and VEGF in 34 cases thyroid micro carcinomas, 30 cases thyroid papillary carcinomas and 20 cases thyroid adenomatous hyperplasia. Results The positive rate of bFGF and VEGF in thyroid micro carcinomas, thyroid papillary carcinomas and thyroid adenomatous hyperplasia was 70%, 50%, 5% and 75%, 50%, 15% respectively. It was no positive expression in normal thyroid tissue beside the carcinomas. The expression of VEGF and bFGF has not different between thyroid micro carcinomas and thyroid papillary carcinomas. But has different between thyroid micro carcinomas and thyroid adenomatous hyperplasia. Conclusions To determined the expression of bFGF and VEGF in thyroid micro carcinomas is signification in predicting the potential metastasis. Thyroid micro carcinomas was as same as thyroid papillary carcinomas with lymph metastasis potential.更多还原