【摘要】 Cedarmycins A和B是近年从放线菌的次生代谢物中分离得到的一种新型的天然抗生素,本文以γ-丁内酯为原料首次合成了该类化合物.其关键步骤为3-溴甲基-5H-呋喃-2-酮与甲醛发生的γ位迁移的Barbier反应.各中间体都通过1H NMR和13C NMR得到证实.最终产品通过1H NMR,13C NMR和HRMS证实与文献所报道相一致.更多还原

【Abstract】 The first synthesis of cedarmycins A and B,which were two novel butyrolactone antibiotics iso-lated from the cultured broth of the actinomycete,was achieved effectively from γ-butyrolactone.The key step was a Barbier reaction of 3-bromomethyl-5H-furan-2-one and formaldehyde to afford the γ-addition product.All structures were confirmed by 1H NMR and 13C NMR spectra.The final compounds were confirmed by 1H NMR,13C NMR and HRMS techniques,and the results are consistent with the reported natural products.更多还原