节点文献

萘丁美酮合成的改进

Technological Improvement of Synthesis for Nabumetone

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【Author】 Chen, Xiaoquan,a Zuo, Zhilib Qiu, Yuqinc Zhou, Xiuyand Zhang, Changjuna Zhai, Hua Shao, Huiyinga Li, Baoqinga (a Chemistry and Chemical Engineering School, Taishan Medical University, Taian 271000) (b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203) (c Library, East China Normal University, Shanghai 200062) (d Chemical Engineering School, Sichuan University, Chengdu 610065)

【机构】泰山医学院化学与化学工程学院；中国科学院上海药物研究所；华东师范大学图书馆；四川大学化工学院；

【摘要】探讨合成萘丁美酮的新方法.以2-甲氧基萘为原料,在超声波作用下并使用新型催化剂合成萘丁美酮.所合成目标化合物经过IR,MS,1HNMR谱确证.通过与文献报道路线的对比,在超声波作用下合成此药物反应时间由原先的13.5h缩短到7.5h,产率由23.9%提高到39.4%.此法在合成萘丁美酮时,能够使合成时间缩短且产率提高.更多还原

【Abstract】 In order to explore new method for synthesis of nabumetone, a synthetic method was investigated by the treatment of 2-methoxy naphthalene under ultrasonic irradiation. The time of the new synthesis method would be shortened from 13.5 h to 7.5 h and yield would be increased from 23.9% to 39.4%. The structure of the synthetic compound was identified by IR, MS and 1H NMR techniques.更多还原

【关键词】合成；萘丁美酮；超声波；改进；
【Key words】 synthesis； nabumetone； ultrasound； improvement；

【文献出处】有机化学 ,Chinese Journal of Organic Chemistry , 编辑部邮箱 ,2010年07期

【分类号】TQ463.2
【被引频次】2
【下载频次】461

知网节下载

节点文献中：

本文链接的文献网络图示:

本文的引文网络

节点文献