【摘要】 结晶诱导动态拆分(CIDR)是对映异构体(或非对映异构体)的原位外消旋作用和选择性结晶过程的耦合.结晶诱导不对称转化(CIAT)包括了CIDR过程,也包括了结晶诱导分离具有单个或多个非对映异构体中心的异构体、顺反式烯烃的过程.概述了CIAT和CIDR在拆分手性化合物中的研究进展.更多还原

【Abstract】 Crystallization-induced dynamic resolution (CIDR) is a combination of racemization of enantiomers either as the free compounds or as diastereomeric salt with a chiral gegenion and selective crystallization. Crystallization-induced asymmetric transformation (CIAT) includes CIDR and other processes, which may include compounds with two or more diastereomeric centers and olefins. The progress of CIAT and CIDR in resolution of chiral compounds is summarized.更多还原