【摘要】 以无水高氯酸铝为催化剂,将芳香醛、芳香胺及亚磷酸酯在无溶剂条件下一锅法反应,高效地合成了α-氨基膦酸酯,该催化剂优于其它已发现的催化剂[如Mg(ClO4)2,BiCl3,AlCl3等],建立了一种适用于含有钝化基团的芳香胺的α-氨基膦酸酯的新合成方法.更多还原

【Abstract】 A reation of an aromatic amine,an aryl aldehyde and a dialkylphosphite took place in one pot with aluminum perchlorate catalyst under solvent-free conditions to afford the corresponding α-aminophosphonates in high yields.Aluminum perchlorate was found to be superior to other catalysts [Mg(ClO4)2,BiCl3,AlCl3 and so on].The Al(ClO4)3-catalyzed α-aminophosphonate synthesis involving aromatic amines with an electron-withdrawing substituent in the present study perhaps is a better method.更多还原