【摘要】 目的研究慢性阻塞性肺病(COPD)合并肺动脉高压患者血清及呼出气冷凝液(EBC)中肿瘤坏死因子α(TNF-α)水平的变化及其临床意义。方法收集稳定期COPD合并肺动脉高压患者20例(A组)、单纯COPD患者20例(B组)及健康体检者15例(C组)血清及EBC标本,并常规行肺功能、动脉血气分析及超声心动图检查。ELISA方法检测血清及EBC中TNF-α水平。结果 A组血清中TNF-α水平(54.93±11.62)ng/L,明显高于B组的(40.73±8.21)ng/L和C组的(22.13±5.51)ng/L(P<0.05)。A组EBC中TNF-α水平(8.93±2.68)ng/L,明显高于B组的(4.72±1.36)ng/L和C组的(3.44±1.27)ng/L(P<0.05)。A组血清及EBC中TNF-α水平均与肺动脉压成正相关(P<0.05)。结论 炎症反应是COPD相关的肺动脉高压形成的重要因素。更多还原

【Abstract】 Objective To study the changes and significances of tumor necrosis factor-α(TNF-α) in serum and exhaled breath condensate(EBC) in patients with chronic obstructive pulmonary disease(COPD) associated with pulmonary arterial hypertension(PAH).Methods Using ELISA assay,TNF-α expression was detected in EBC and serum of 20 COPD cases associated with PAH(group A),20 single COPD cases(group B) and 15 normal persons(group C).Lung function,arterial blood gase and echocardiography were assayed in all cases.Results The level of TNF-α in serum was higher in group A than that in groups of B and C[(54.93±11.62) ng/L vs.(40.73±8.21) ng/L and(22.13±5.51) ng/L] (P<0.05).So did that in EBC [(8.93±2.68) ng/L vs.(4.72±1.36) ng/L and (3.44±1.27) ng/L](P<0.05).Pulmonary arterial pressure in group A was positively correlated with the levels of TNF-α in serum and EBC(P<0.05).Conclusion Inflammation response is an important factor in COPD-related PAH.更多还原