【摘要】 目的评价经血清筛查为高风险但不愿接受羊水产前诊断孕妇的妊娠结局。方法采用时间分辨荧光技术血清AFP+βhCG二联筛查,对高风险孕妇经遗传咨询并知情是否接受羊水产前诊断。对所有筛查高风险孕妇妊娠结局进行病历查询或电话随访,记录结局、分娩方式、新生儿体重、评分等。结果 24408例妊娠妇女经孕中期血清二联筛查有1268例为高风险,筛查阳性率达5.19%。441例(40.50%)血清筛查染色体异常高风险孕妇不愿接受羊水染色体产前诊断,经随访,共发现不良妊娠结局18例;其中,唐氏综合征新生儿2例,另有9例B超检查发现胎儿畸形,4例发生难免流产,死胎2例,先天性心脏病1例。结论提高羊水诊断率对降低出生缺陷具有重要的积极作用。更多还原

【Abstract】 Objective To evaluate the pregnancy outcomes of high-risk pregnant women without amniotic fluid test for prenatal diagnosis.Methods Serum AFP and free-β-HCG of prenatal women were detected by time-distinguished fluorescence immunoassay.Multicalc software was used to calculate Down’s syndrome risk value.Results Of 24408 trimester women,1268 cases were found to be at high risk (5.19%) and 441(40.50%) cases with abnormal serum chromosome refused to accept amniotic fluid test for prenatal diagnosis.The follow-up showed that there were 18 cases had adverse pregnancy,of whom Down’s syndrome was diagnosed in 2 infants,deformities in 9 infants,dead fetus in 2 cases and one infant with congenital heart disease.Conclusion To improve the diagnosis rate of amniotic fluid is an important step to reduce birth defects.更多还原