【摘要】 目的:通过对比正常对照组与帕金森病患者脑灰质核团T2弛豫时间,定量分析帕金森病T2弛豫时间的变化规律。方法:选取17例帕金森病患者及20例健康志愿者,定量测量脑双侧CA、PM、GP、SNc的T2弛豫时间,将帕金森病患肢对侧和未出现症状肢体对侧相对应部位的CA、PM、GP、SNc的T2弛豫时间进行对比分析,并分别与正常对照组进行比较。结果:帕金森病组SNc的T2弛豫时间较正常对照组缩短(P<0.05),GP的T2弛豫时间较正常对照组升高(P<0.05),但在PD患者患肢对侧和同侧之间无显著性差异(P值>0.05)。结论:帕金森病患者脑SNc的T2弛豫时间降低,GP的T2弛豫时间升高,T2弛豫时间定量测量可以作为PD的一种无创性检测方法。更多还原

【Abstract】 Objective:To quantitatively analyze the variations of brain iron in PD by measuring T2 relaxation time of brain gray nucleus.Methods:Choosing 17 PD patients and 20 healthy volunteers,T2 relaxation time was measured in both sides of CA,PM,GP and SNc.Results:T2 relaxation time decreased in SNc and increased in GP,when compared to the controls(P<0.05).But there were no significant difference between the opposite side of affected extremities and those of asymptomatic extremities(P>0.05).Conclusion:The T2 relaration time decreased in SNc and increased in GP in PD patients.The quantitative measurement of T2 can be used as an atraumatic method of PD diagnosis.更多还原