【摘要】 目的:探讨大剂量氨溴索对急性百草枯中毒致肺损伤患者血清TNF-α与IL-6的影响。方法:31例急性百草枯中毒致肺损伤患者随机分为治疗组(16例)及对照组(15例)。所有患者均予常规治疗,治疗组在此基础上加用氨溴索20mg/(kg·d)静脉滴注,每12h1次,连续治疗3d。双抗体夹心ELISA法检测患者治疗前及治疗3d后外周血血清TNF-α与IL-6水平,同时行肺损伤评分(LIS)评价损伤程度。结果:治疗后两组患者血清TNF-α、IL-6水平及LIS均比治疗前明显下降(P均<0.01),治疗后治疗组上述指标均比对照组明显改善(P均<0.05)。结论:大剂量氨溴索可抑制TNF-α、IL-6的表达,减轻急性百草枯中毒导致的肺损伤。更多还原

【Abstract】 Objective:To investigate the effects of high-dose ambroxol on serum TNF-α and IL-6 of patients with pulmonary injury caused by acute paraquat poisoning. Methods:Thirty-one patients with pulmonary injury caused by acute paraquat poisoning were randomly divided into treatment group (n=16) and control group (n=15). Both groups were treated with conventional therapy. Treatment group were given ambroxol 20 mg/(kg·d)intravenously guttae every 12 h for 3 days. Serum TNF-α and IL-6 were measured by ELISA before and after treatment,and lung injury score (LIS) was also assessed in all subjects. Results:Levels of serum TNF-α and IL-6,and LIS in both groups were significantly lower after treatment(P<0.01). Furthermore,treatment group showed significantly more lower than control group (P<0.05). Conclusion:High-dose ambroxol can inhibit exrpression of serum TNF-α and IL-6,reduce the degree of pulmonary injury caused by acute paraquat poisoning.更多还原