【摘要】 目的:探讨肿瘤标志物甲胎蛋白(AFP)、癌胚抗原在肝硬化和原发性肝癌(PHC)中的诊断价值。方法:对PHC组45例、肝硬化组46例、肝炎组50例和正常对照组42例,检测血清AFP、CEA和CA19-9水平(前3组患者在接受治疗前检测)。结果:PHC组血清AFP、CEA、CA19-9水平均明显高于肝炎组及正常对照组,差异有非常显著性(P<0.05)。PHC组血清AFP、CEA和CA19-9阳性率分别为68.89%、44.44%、91.11%,3种方法联合检测PHC,阳性检出率达93.3%。结论:血清AFP、CEA和CA19-9联合检测具有互补作用,可提高PHC的诊断率。更多还原

【Abstract】 Objective:To investigate the clinical value of tumor marker alpha fetoprotein(AFP),CEA and CA19-9 in the diagnoss of liver cirrhosis and primary hepatic cancer (PHC).Methods:AFP,CEA and CA19-9 in serum were studied in 45 patients with PHC,46 with liver cirrhosis,50 with hepatitis,and 42 healthy individuals.Results:The serum AFP,CEA and CA19-9 in PHC were significantly higher than those in the hepatitis and healthy individuals (P<0.05). The positive detection rate of AFP,CEA and CA19-9 in PHC was 68.8% ,44.4% and 91.11% respectively.Combined assay of AFP,CEA and CA19 -9 increased the detecting rate up to 91.11%. Conclusion:The combining AFP,CEA and CA19-9 examination has complementary function,which is superior to any single marker examination and can greatly increase the detecting rate of PHC and is valuable in diagnosing PHC.更多还原