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大蒜素微球体外释放研究
Study on release of diallyl trisulfide microspheres in vitro
【摘要】 目的:研究聚乳酸大蒜素微球释放规律。方法:采用动态透析技术研究聚乳酸大蒜素微球的体外释药性能,并用高效液相色谱法测定大蒜素含量,以累计释药百分率进行不同模型的拟合。结果:聚乳酸大蒜素微球的释放曲线符合双相动力学方程。结论:聚乳酸大蒜素微球具有良好的缓释作用。
【Abstract】 Objective:To study the release of diallyl trisulfide microspheres in vitro. Methods:The rules of drug release in vitro from diallyl trisulfide microspheres were observed by dynamic penetration system and HPLC. Results:The profile curve of diallyl trisulfide microspheres was fit for double phase dynamic modle. Conclusion:Diallyl trisulfide microspheres have obviously sustained effect.
【关键词】 大蒜素;
聚乳酸;
微球;
体外释放;
【Key words】 Diallyl trisulfide (DATS); Poly lactic-acid; Microspheres; Release in vitro;
【Key words】 Diallyl trisulfide (DATS); Poly lactic-acid; Microspheres; Release in vitro;
- 【文献出处】 现代医药卫生 ,Modern Medicine & Health , 编辑部邮箱 ,2010年17期
- 【分类号】R944
- 【被引频次】1
- 【下载频次】104