【摘要】 目的:探讨老年慢性心力衰竭(CHF)患者高敏C反应蛋白(hs-CRP)、血尿酸(UA)的浓度变化及意义。方法:选择67例NYHAⅡ一Ⅳ级老年CHF患者(心衰组)及29例正常老年人(正常对照组),测定血清UA、hs-CRP的水平,超声心动图测量左心室射血分数(LVEF)。结果:心衰组患者血清hs-CPR[(8.78±4.35)mg/L∶(1.27±0.48)mg/L]、UA[(451±83)μmol/L∶(289±25)μmol/]均较正常对照组明显增高(P均<0.01)。且随着NYHY心功能级别增高,血UA水平逐渐升高,其组间差异性显著(P<0.01),二者呈正相关(r=0.39;P<0.01)。血清hs-CPR随NYHA分级的增加而升高,但组间无显著性差异(r=0.187,P=0.079)。血UA水平与血清hs-CRP无显著相关(r=0.389,P=0.065)。结论:老年慢性心力衰竭患者血尿酸水平与心衰分级有很好的相关性,它结合NYHA分级方法及左室射血分数能更好地反映心衰患者的严重程度。更多还原

【Abstract】 Objective:To study the significance of concentration change of serum uric acid and high sensitive C-reactive protein(hs-CRP)in aged patients with chronic heart failure.Methods: The level of serum uric acid(UA)and hs-CRP were detected and left ventricular ejection fraction was estimated by echocardiography in 67 aged patients with congestive heart failure(CHF,NYHAⅡ~Ⅳ class,CHF group)and 29 normal persons(normal control group).Results: The hs-CPR [(8.78+4.35) mg/L vs.(1.27+0.48) mg/L]、UA[(451+83) μmol/L vs.(289+25) μmol/L] in CHF group significantly increased compared with those of normal control group(P<0.01).The serum UA level gradually increased follow NYHA class increased,its interclass difference was significant(P<0.01),and there was positive correlation between UA level and NYHA class(r=0.39;P<0.01).The serum hs-CRP level also gradually increased follow NYHA class increased,but its interclass difference was no significant(P>0.05),and there was no correlation between hs-CRP level and NYHA class(r=0.389,P=0.065).Conclusion: There is positive correlation between UA level and NYHA class in aged patients with chronic heart failure,UA level combined NYHA class and LVEF would better reflect CHF severity.更多还原