【摘要】 目的:探讨比索洛尔治疗慢性心力衰竭患者的疗效。方法:104例慢性心力衰竭患者被随机分成两组:对照组52例,予以常规用药(强心、利尿、扩血管)+咪哒普利治疗;治疗组52例,在常规用药+咪哒普利基础上加用比索洛尔治疗,疗程12～16周,观察治疗前后心功能、左室射血分数(LVEF)、左室舒张末内径(LVEDd)、左室收缩末内径(LVESd)、心率及血压等指标的变化。结果:治疗组总有效率明显高于对照组(92.31%:73.08%,P<0.05);治疗组治疗后LVESd较治疗前显著降低[(49.86±5.20)mm:(61.80±4.58)mm,P<0.05],且较对照组(57.65±4.20)mm降低更显著,P<0.05,两组治疗后LVEF均有明显增高(P<0.05～0.01),且治疗组明显高于对照组[(48.84±4.45)%:(37.58±3.15)%,P<0.05],治疗组收缩压、舒张压、心率均较治疗前明显改善(P<0.05～0.01),且舒张压[(69.4±12.98)mmHg:(75.97±13.62)mmHg]、心率[(70.99±10.7)次/min:(75.73±9.4)次/min]较对照组明显降低(P均<0.05)。结论:在常规用药+咪哒普利基础上加用比索洛尔治疗慢性心力衰竭患者疗效更显著。更多还原

【Abstract】 Objective:To observe the effect of Bisoprolol for the patients with chronic heart failure.Methods:A total of 104 patients with chronic heart failure were divided into two groups.The control group(n=52) was treated by routine medicines (digitalis、diuretic、 blood-vessel dilator) combined Imidapril.The treatment group(n=52) was treated by routine medicines combined Imidapril and Bisoprolol.The course of treatment was 12-16 weeks.The changes of the LVEF、LVEDd、 LVESd、 heart rate (HR)and blood pressure were observed before and after treatment.Results:The total effective rate of treatment group was higher than that of control group(92.31% vs.73.08%,P<0.05).The levels of LVSDd significantly decreased in treatment group [(49.86±5.20)mm vs.(61.80±4.58)mm,P<0.05]and more than that of control group [(49.86±5.20)mm vs.(57.65±4.20)mm,P<0.05]after treatment.The levels of LVEF improved(P<0.05～0.01)in both two groups before and after treatment,compared with control group,that of treatment group increased more than[(37.58±3.15)% vs.(48.84±4.45)%,P<0.05].SBP、DBP and HR significantly improved(P<0.05～0.01)in treatment group,DBP[(69.4±12.98)mmHg vs.(75.97±13.62)mmHg] and HR[(70.99±10.7)vs.(75.73±9.4)] were more decreased than those of control group (P<0.05 all).Conclusion:It is more effect that the routine medicines and Imidapril combined Bisoprolol for the patients with chronic heart failure.更多还原