【摘要】 尿酸是人体嘌呤代谢的终产物。有研究认为尿酸在人体血液是重要的抗氧化剂,且对维持血压和血容量有意义。流行病学资料显示高尿酸血症是高血压、代谢综合征、冠状动脉粥样硬化性心脏病的独立危险因子。近年来大量研究表明血尿酸水平的升高与慢性心力衰竭、肾功能损害、胰岛素抵抗、血管内皮功能紊乱等高度相关。血管内皮功能的受损是某些心血管疾病的始动因素。因此,深入认识无症状高尿酸血症的危险性及早干预高尿酸血症改善血管内皮功能有重要的临床意义。更多还原

【Abstract】 Uric acid is the end product of purine metabolism in humans.It is considered an important antioxidant in plasma and perhaps helps to control blood pressure and maintain circulating blood volume.However,epidemiologic evidence indicates that uric acid is an independent risk factor in hypertension and coronary heart disease.A number of studies show that elevated serum urate levels have long been closely associated with chronic heart failure,insulin resistance and vascular endothelial dysfunction.Vascular endothelial dysfunction acts as an initiating agent in some cardiovascular diseases.Therefore,it may have important clinical implications for assisting in the recognition process of asymptomatic hyperuricemia allowing for early intervention.更多还原