【摘要】 目的探讨不同剂量阿司匹林预防非瓣膜性心房颤动(房颤)患者发生血栓栓塞的有效性和安全性。方法将240例非瓣膜性房颤患者随机分为阿司匹林1组(150mg/d)和阿司匹林2组(250~300 mg/d)各120例。常规门诊随访,记录两组患者终点事件和不良反应情况。结果两组比较,阿司匹林2组主要终点事件发生率2.50%(3/120),明显低于阿斯匹林1组8.33%,(10/120),相对危险性下降50%以下,但主要终点事件和次要终点事件两组间无统计学意义(P>0.05)。结论两组相比,阿司匹林2组可明显降低非瓣膜性房颤患者缺血性脑卒中的发生率,且出血的发生率无明显增加,250~300 mg/d阿司匹林安全有效。更多还原

【Abstract】 Objective To investigate the effect of aspirin on the prevention of thromtmembolism in nonvalvular atrial fibrillation.Methods There were 240 patients diagnosed as nonvalvular atmil fibrillation treated with aspirin 150mg(LD) or 250~300mg(HD) once a day.The side-effect and destination events including stroke,death,periphexal arteries embolism,TIA,acute mvocardial infarction and serious bleeding were observed.Results The incidences of destination events of HD and LD were 2.50% and 8.33%,respectively(P<0.05).The relative risk of HD decreased 50% compared with that of LD.There was no patients with serious bleeding in the tow groups.Conclusion The study demonstrats that patients with nonvalvular atrial fibrillation receive 250-300ng aspirin once day can significantly reduce the risk of the thromboembolism.更多还原