【摘要】 目的探讨老年结直肠癌的临床病理学特点。方法对2004年5月～2008年5月在中南大学湘雅二医院老年外科接受手术治疗的396例结直肠癌患者的临床资料进行回顾性分析,比较老年组和非老年组临床病理特点的不同。结果老年组右半结肠癌、直肠癌比例分别为23.5%(48/204)、49.0%(100/204),非老年组比例为14.6%(28/192)、60.4%(116/192)。老年组Dukes A、B、C期比例分别为9.8%、45.1%、28.4%,非老年组比例为3.6%、34.9%、45.8%。老年组高分化肿瘤比例为26.0%,低分化肿瘤比例8.3%,非老年组高分化比例10.9%,低分化比例27.6%。老年组合并息肉92例(45.1%),非老年组合并息肉25例(13.0%)。与非老年人相比,老年结直肠癌患者右半结肠癌比例高,直肠癌比例低,临床分期早,组织分化好,结直肠息肉伴发率高,差异有统计学意义(P<0.05)。结论老年结直肠癌右半结肠癌比例高,生物学行为好,结直肠息肉伴发率高,应重视结肠镜检查并采取积极的治疗措施。更多还原

【Abstract】 Objective To investigate the clinicopathological characteristics of senile patients with colorectal cancer.Methods The clinical data of 396 patients with colorectal cancer who received surgical treatment in our hospital from May 2004 to May 2008 were retrospectively analyzed.The clinicopathological characteristics were compared between the senile and non-senile patients.Results The proportions of right hemicolonic and rectal cancer were 23.5% and 49.0% respectively in senile group,14.6% and 60.4% in non-senile group(P=0.035).The proportions of Dukes A,B,and C staged tumor were 9.8%,45.1% and 28.4% respectively in senile group,3.6%,34.9% and 45.8% in non-senile group(P=0.001).The proportions of the patients with well-differentiated and poorly differentiated tumors were 26.0% and 8.3% in senile group,10.9% and 27.6% in non-senile group(P=0.000).Ninety two patients in senile group had concomitant colorectal polyps,while only 25 patients in non-senile group(P=0.000).Conclusions The characteristics of senile patients with colorectal cancer include a higher proportion of right hemicolonic tumors,better oncobiological behavior and a higher incidence of concomitant colorectal polyps.Total colonoscopy should be emphasized in the diagnosis of colorectal cancer and more active surgical treatment should be adopted in senile patients.更多还原