【摘要】 目的:观察次声对心肌梗死后大鼠心肌纤维化的影响及相关机制研究。方法:将30只SD大鼠随机分为3组,即假手术组、心肌梗死组及次声治疗组,每组10只。采用低声压级水平次声对心肌梗死大鼠治疗1周(2次/d,0.5 h/次),观察心肌胶原和血浆NO和血管紧张素-Ⅱ(AngⅡ)及大鼠心功能的变化。结果:与心肌梗死组大鼠比较(未治疗组),次声治疗组大鼠心肌胶原表达明显减少,血浆NO含量显著增加(P<0.01),血浆AngⅡ含量显著降低(P<0.01),心功能明显改善(P<0.01)。结论:低声压级水平次声治疗能够明显减轻心肌梗死后大鼠心肌纤维化,其作用可能与血浆NO及AngⅡ含量变化有关。更多还原

【Abstract】 AIM: To observe the changes of cardiac fibrosis and its underlying mechanism after acute myocardial infarction in rats.METHODS: Thirty male Sprague Dawley rats were randomized to control group,infarction group and infrasound treatment group(10 rats/group).Rats in the infrasound treatment group were treated with infrasound for 7 days,0.5 h,twice/day.Collagen expression of rat myocardium and contents of NO and Ang-II in rat plasma and rat heart function were observed.RESULTS: Compared with those in the infarction group,the collagen expression of rat myocardium increased in the infrasound treatment group(P<0.01),the contents of NO in rat plasma significantly decreased(P<0.01),the contents of ET-1 in rat plasma significantly increased(P<0.01),and heart function was significantly improved.CONCLUSION: Infrasound treatment significantly assuages the cardiac fibrosis of rats after myocardial infarction,which may be relative with the changes of NO and Ang-II.更多还原