【摘要】 目的:用心肺运动试验中的氧摄取动力学、无氧阈及心肺储备功能对冠状动脉狭窄的严重程度进行评估。方法:对68例胸痛的患者行心肺运动试验,彩色心超测定左心室射血分数(LVEF),及冠心病造影,根据冠状动脉主要血管的狭窄程度进行分组,狭窄程度<50%(29例),50%～70%(25例),>70%(14例),组间进行二氧化碳呼吸当量、氧摄取动力学及无氧阈、LVEF等的比较。结果:与<50%组相比,50%～70%组的中VO2peak[(20.86±6.36)vs.(26.63±4.51)mL.kg-1.min-1,P<0.001]、VCO2[(1.37±0.50)vs.(1.72±0.49)L/min,P<0.05]、AT[(1.24±0.38)vs.(1.48±0.32)L/min,P<0.05]、O2pulsepeak[(10.34±3.27)vs.(12.33±2.53)mL/beat,P<0.05]有差异有统计学意义,<70%组中的,除了VO2peak、VCO2、AT、O2pulsepeak有显著性差异,HRpeak[(120.50±14.00)vs.(139.03±18.97)beats/min,P<0.01]、VE/VCO2@AT[(31.23±4.89)vs.(28.88±4.04),P<0.05]、VD/VT(Est)@Peak[(0.21±0.05)vs.(0.17±0.03),P<0.01]同时也有有显著性差异;与50%～70%相比,>70%组中的VD/VT(Est)@Peak有显著性差异。结论:冠状动脉狭窄程度大于50%可能与VO2peak、VCO2、AT、O2pulsepeak有一定的相关性,冠状动脉狭窄程度>70%可能与HRpeak、VE/VCO2@AT、VD/VT(Est)@Peak有一定的相关性。更多还原

【Abstract】 Objective:The objective of this study was to investigate the effect on evaluation of stenosis severity of coronary artery with the kinetics of oxygen uptake（VO₂）,anaerobic threshold（AT）and cardiopulmonary functional capacity during the onset of exercise in patients with suspected angina.Methods:Treadmill graded exercise tests with gas analysis 、ultrasound cardiography、coronary angiography were conducted on sixty-eight patients with suspected angina.According to stenosis severity of coronary artery,sixty-eight patients were divided into three groups:less than 50% stenosis（39）,50%-70% stenosis（29）,and more than 70% stenosis（14）.Evaluate the differences of cardiopulmonary function between groups.Results:Compared with less than 50% stenosis group,50%-70% stenosis group showed statistical significance in VO₂peak、VCO₂、AT、O₂ pulse peak,more than 70% stenosis group not only shown showed statistical significance in VO₂peak、VCO₂、AT、O₂ pulse peak,but also showed statistical significance in HR peak[（120.50±14.00）vs.（139.03±18.97）beats/min,P<0.01]、 VE/VCO₂@AT[（31.23±4.89）vs.（28.88±4.04）,P<0.05] and VD/VT（Est）@Peak[（0.21±0.05）vs.（0.17±0.03）,P<0.01].Compared with 50%-70% stenosis,more than 70% stenosis group showed statistical significance in VD/VT（Est）@Peak.Conclusions:CEPT have potential value in evaluating stenosis severity of coronary artery.HR peak、 VE/VCO₂@AT and VD/VT（Est）@Peak have some connection with the severity of coronary heart disease.更多还原