【摘要】 目的:探讨中晚期食管癌动脉灌注化疗的疗效、影响疗效的因素和并发症的预防。材料与方法:46例食管癌均经食管钡剂造影和病理组织学检查确诊,其中鳞癌45例,腺癌1例。全部病例均行相应食管节段供血动脉选择性插管造影,经导管灌注化疗药物。结果:46例食管癌动脉灌注化疗后近期临床总有效率(CR+PR)82.6%;多血管型肿瘤疗效(91.2%)优于少血管型(58.3%)(x2=4.57,p<0.05),多次治疗疗效(96.6%)明显好于单次治疗(58.8%)(x2=8.15,p<0.01)。1、2、3年总生存率分别为84.8%(39/46)、37%(17/46)、17.4%(8/46)。生存3年以上者均为多次治疗的CR患者。严重并发症有大出血1例。结论:食管癌动脉灌注化疗疗效显著,是中晚期食管癌综合治疗的一种主要方法。应重视预防严重并发症发生。更多还原

【Abstract】 Purpose:To evaluate the efficacy and to prevent complications of selective transarterial chemotherapy in the treatment of advanced esophageal cancer.Materials and Methods:46patients with histologically verified esophageal cancer,45 cases of squamous cell carcinoma and 1 case of adenocarcinoma,were treated with selective transcatheter arterial infusion chemotherapy.Results:The overall response rate (CR+PR) of the therapy was 82.6%.The better results occurred in patients with hypervascular tumor compared with hypovascular tumor and also the effect of multiple infusion excelled that of single treatment .The 1,2 and 3 years survial rate reached 84.8%(39/46),37%(17/46),17.4%(8/46).The patients of over 3 years survival were complete symptomlessness after multiple infusion.Severe complication was massive heamorrhaye of esophagus.Conclusion:Transarterial chemotherapy for patients with esophageal cancer is effective and reliable.It should be regarded as a major part of multidisciplinary therapy for esophageal cancer. Much attention should be paid to the prevention of serious complication.更多还原