【摘要】 目的探讨新生儿高胆红素血症患儿心肌酶谱及超敏C-反应蛋白改变的临床意义。方法选取2007年1月～2009年10月,我院收治的90例足月新生儿,高胆红素组60例,对照组(正常新生儿)30例,高胆红素组治疗前、后及对照组均行股静脉穿刺采血作肝功能、心肌酶谱(CK、CK-MB、LDH、AST)及hs-CRP检测。结果高胆红素组治疗前心肌酶谱及超敏C-反应蛋白浓度与对照组比较明显升高,差异有统计学意义(p<0·01);高胆红素组治疗后心肌酶谱及超敏C反应蛋白浓度趋于正常(p>0·05);治疗前后有非常显著性差异(p<0·01)。结论新生儿高胆红素血症可发生心肌损害,早期心肌酶谱与超敏C-反应蛋白测定有助发现其心肌损害,具有临床指导意义。更多还原

【Abstract】 Objective To analyze the clinical significance of myocardial enzymes and high sensitivity C-reactive protein (hsCRP) in neonatal hyperbilirubinemia.Methods 90 cases of full-term newbones in the period from January 2007 to October 2009 at our hospital were determined.The hepatic function test,myocardial enzymes (CK,CK-MB,LDH,AST) and hsCRP were assayed in 60 cases of neonatal hyperbilirubinemia both in prior-treatment and post-treatment,and in 30 cases of healthy newborns via femoral vein puncture.Results The level of myocardial enzymes and hsCRP were obviously increased in the group of hyperbilirubinemia compared with the group of healthy newborns (p<0.01) and were gradually tended to be normal level after treatment.The level of myocardial enzymes and hsCRP had significant difference between prior-treatment and post-treatment in neonatal hyperbilirubinemia(p<0.01).Conclusion Myocardial injury can occur in neonatal hyperbilirubinemia.The early detection of myocardial enzymes and hsCRP can be used as a valuable monitoring index in clinical practice.更多还原