【摘要】 [目的]了解河南省食源性沙门菌的耐药性变迁情况,为相关部门政策制定提供依据。[方法]沙门菌检测参照GB/T4789.4-2008方法进行;药敏试验采用纸片法,操作及结果判读参照美国临床实验室标准化协会(CLSI/NCCLS)抗微生物药物敏感性试验执行标准(2006年)。[结果]对2003～2008年检出的278株食源性沙门菌进行药物敏感试验,6年间食源性沙门菌对青霉素类、第三代头孢类、喹诺酮类、氨基糖苷类、氯霉素类以及四环素类抗生素产生不同程度的耐药,耐药性日益严重,耐药谱扩大,出现对多种抗生素耐药的多重耐药(MDR)菌株,最多的是对11种抗生素产生耐药。[结论]河南省食源性沙门菌耐药形势严峻,耐药性沙门菌尤其是多重耐药性沙门菌成为公共健康的潜在威胁。更多还原

【Abstract】 [Objective] To understand resistance changes of foodborne Salmonella in Henan,and provide a basis for relevant departments to set up policy.[Methods] Salmonella testing was carried out referring to GB /T4789.4-2008.Antimicrobial susceptibility testing was performed by using Kirby-Bauer Method.The results of examination were judged according to NCCLS(2006).[Results] We performed antimicrobial susceptibility test for 278 foodborne Salmonella bacteria from 2003 to 2008,and foodborne Salmonella strains were resistant to penicillins,third-generation cephalosporins,quinolones,aminoglycosides and chloramphenicol classes as well as tetracycline antibiotics in different degrees.The antimicrobial resistance increased in bac-terial strain,and the resistance spectrum was expanded.Salmonella bacteria presented resistant to multiple antibiotics,and the most resistant showed to be 11 kinds of antibiotics.[Conclusion] Resistance of food-borne Salmonella is serious in Henan,and drugresistant Salmonella,especially multi-drug resistance of Salmonella become a potential threat to public health.更多还原